I prerecorded the audio below (8 minutes) to go with these PDF slides for AD/PD 2023 in Gothenburg, Sweden.
Disease Progression Modelling on MRI data Identifies Subtypes with Cognitive Heterogeneity in A4 Study Preclinical Trial Cohort
TL;DR: We used SuStaIn to find MRI-based subtypes in the screening data of the A4 Study clinical trial (preclinical Alzheimer’s disease) and leveraged the ADNI observational dataset to link these subtypes to heterogeneous cognitive decline.
This could potentially wash out any treatment effect (if present) in the A4 study trial. This work was completed before the results of A4 were known.
- Full paper preprint: Shand et al., medRxiv 2023
- SuStaIn original paper: Young et al., Nature Communications 2018
- A4 Study: a4study.org