New paper on data-driven progression subtypes in Alzheimer’s disease

Latest paper is an amazing collaboration led by the wonderful Jake Vogel that pulled together the largest database so far of tau PET imaging of Alzheimer’s pathology in the living brain, then unleashed Alex Young’s SuStaIn algorithm to discover four previously unknown/uncharacterised subtypes.

It turns out that these are quite common (as in not rare), and they have unique symptom profiles too.

https://www.nature.com/articles/s41591-021-01309-6

I could dig in, but here’s what Jake had to say on twitter:

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